Extracolonic Manifestations of Lynch Syndrome

Brian J. Bansidhar

doi:10.1055/s-0032-1313781

Clinics in Colon and Rectal Surgery, Table of Contents

Clin Colon Rectal Surg 2012; 25(02): 103-110
DOI: 10.1055/s-0032-1313781

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Extracolonic Manifestations of Lynch Syndrome

Brian J. Bansidhar

¹Department of Colon and Rectal Surgery, Saint Vincent Health Center, Erie, Pennsylvania.

› Author Affiliations

Abstract

Lynch syndrome has classically been defined by several predominant malignancies. Initial clinical criteria for diagnosis of Lynch syndrome would miss 40% of affected individuals. As time has passed, our understanding of Lynch syndrome has evolved and will continue to do so. The number of cancer types that are included in the Lynch phenotype is growing. This has allowed clinicians to redefine Lynch syndrome, at risk populations, screening needs, and diagnostic criteria. Inclusion of extracolonic malignancies and alternative genetic pathways gives new insight into the true prevalence and penetrance of Lynch syndrome.

Keywords

Lynch syndrome - extracolonic malignancies - mismatch repair genes - atypical phenotype

Full Text

References

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